2-Mercaptoethanol → HCID 57901698, compound

Participants

Reaction Steps

A solution (2 mL) of N-{2-[5-(chloromethyl)-1,3-thiazol-2-yl]-1H-indol-7-yl}-N-(2-ethoxyethyl)thiophene-2-sulfonamide (18 mg) and triethylamine (14 mg), 2-mercaptoethanol (10 mg) in N,N-dimethylformamide was stirred at room temperature for 18 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate. The extract was concentrated, and the residue was purified by preparative HPLC to give the title compound (5.9 mg, yield 30%).

Provenance & Evidence