2-Fluoropyridine-3-boronic acid → HCID 86705791, compound

HRID 1851640Notes

Reaction equation

HRID 1851640 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:20][C:19](=[O:21])[N:18]([CH3:22])[C:17]([NH:23]C(=O)OC(C)(C)C)=[N:16]3)[C:14]3[CH:13]=[C:12]([Cl:31])[N:11]=[C:10]([F:32])[C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[F:33][C:34]1[C:39](B(O)O)=[CH:38][CH:37]=[CH:36][N:35]=1>>[NH2:23][C:17]1[N:18]([CH3:22])[C:19](=[O:21])[CH2:20][C@:15]2([C:14]3[CH:13]=[C:12]([Cl:31])[N:11]=[C:10]([F:32])[C:9]=3[O:8][C:5]3[C:4]2=[CH:3][C:2]([C:39]2[C:34]([F:33])=[N:35][CH:36]=[CH:37][CH:38]=2)=[CH:7][CH:6]=3)[N:16]=1

Participants

3

Reactant 2

HCID 27832702-Fluoropyridine-3-boronic acidHCID 86705792HCID 86705792, compound

Product 1

HCID 86705791HCID 86705791, compound

Procedure

The title compound was synthesized by procedures and steps analogous to those described in Example 12 above, but using (S)-tert-butyl 7-bromo-3-chloro-1-fluoro-1′-methyl-6′-oxo-5′,6′-dihydro-1′H-spiro[chromeno[2,3-c]pyridine-5,4′-pyrimidine]-2′-ylcarbamate (Example 1-B) and 2-fluoropyridin-3-ylboronic acid.

Sources & evidence

ORD record
ord-b38974652b3c4685816373e1db5d94c4
Source dataset
uspto-grants-2015_02
Patent number
US08957083B2

Reaction notes

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