HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimorpholinomethane → Molindone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimorpholinomethane | HCID 21839 | — |
| Reactant | 3-Ethyl-2-methyl-1,5,6,7-tetrahydroindol-4-one | HCID 80204 | — |
| Product | Molindone | HCID 23897 | — |
Reaction Steps
In a specific embodiment, the invention provides a method of manufacturing molindone through a 3-step process, wherein in the 1st step 2,3-pentadione is reacted with hydroxylamine hydrochloride to produce 2,3-pentanedione-2-oxime (SUMO-1); in the 2nd step 2,3-pentanedione-2-oxime and 1,3-cyclohexanedione are reacted to produce 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole (SUMO-2); and in the 3rd step 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole reacts with bismorpholinomethane to produce molindone (SUMO-3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957206B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-866f3adff819446f94c1b2fefcba2e50 |
| Source note | uspto-grants-2015_02 |