Ethanol → Carfentrazone-ethyl

HRID 1851698Notes

Reaction equation

HRID 1851698 reaction equation
[Cl:1][CH:2]([CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[C:17](=[O:18])[N:16]([CH:19]([F:21])[F:20])[C:15]([CH3:22])=[N:14]2)[C:10]([F:23])=[CH:9][C:8]=1[Cl:24])[C:3]([OH:5])=[O:4].[CH2:25](O)[CH3:26]>C1C=CC=CC=1>[CH3:25][CH2:26][O:4][C:3]([CH:2]([Cl:1])[CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[N:14]=[C:15]([CH3:22])[N:16]([CH:19]([F:20])[F:21])[C:17]2=[O:18])[C:10]([F:23])=[CH:9][C:8]=1[Cl:24])=[O:5]

Participants

4

Reactant 2

HCID 702EthanolHCID 443229Carfentrazone

Product 1

HCID 86222Carfentrazone-ethyl

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

adding 1 mol of the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorophenyl}propionic acid of the step (1), 4˜10 mol of ethanol and 0.03˜0.2 mol of an acid catalyst into 6˜12 mol of the solvent of benzene class; refluxing the reaction mixture until an esterification is completed; washing successively with water, with aqueous alkali base and then with water; and removing the solvent totally from the organic layer, to give a product carfentrazone-ethyl.

Workup

  1. temperaturerefluxing the reaction mixture until an esterification
  2. washwashing successively with water, with aqueous alkali base
  3. customand removing the solvent totally from the organic layer

Sources & evidence

ORD record
ord-966f7c3946f24150af6c7d28d633701b
Source dataset
uspto-grants-2015_02
Patent number
US08957220B2

Reaction notes

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