反应详情

A degassed methanol solution (4 mL) containing RuCl2((R)-3,5-xylylBINAP) ((2R)-DAIPEN) (10 mg), 3-methoxymethylamino-1-(2-thienyl)-1-propanone (160 mg), potassium tert-butoxide (100 mg) and methanol (10 mL) were charged in a glass autoclave under an argon gas flow. After deaeration and replacement by argon, hydrogen was introduced to a predetermined pressure. The resulting solution was hydrogenated at 20□ for 12 hours. Upon completion of hydrogenation, the reaction mixture was concentrated to give the objective compound as an oily product (161 mg, 95% ee; purity: 95.8% by HPLC assay).

1. additionwere charged in a glass autoclave under an argon gas flow
2. concentrationUpon completion of hydrogenation, the reaction mixture was concentrated
3. customto give the objective compound as an oily product (161 mg, 95% ee; purity: 95.8% by HPLC assay)