Aluminium lithium hydride → HCID 24803564, compound

Participants

Reaction Steps

The title compound (11 mg, 38%) was prepared by reduction according to the method described for the preparation of 2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-N-(2,2,2-trifluoroethyl)-1,3-benzothiazol-6-amine by the use of ethyl {2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1,3-benzothiazol-6-yl}carbamate (37 mg, 0.088 mmol) as starting material, and lithium aluminiumhydride (10 mg, 0.26 mmol) as reagent, with the following modification: The reaction mixture was stirred at reflux for 1 h then at r.t. o.n. The crude was purified by prep. HPLC, to give the title compound (11 mg) as a pale yellow solid. 1H NMR (MeOH-D4) δ 8.59 (d, 1 H) 7.98 (dd, 1 H) 7.56 (d, 1 H) 6.93 (d, 1 H) 6.82 (d, 1 H) 6.73 (dd, 1 H) 3.55-3.69 (m, 4 H) 2.74 (s, 3 H) 2.48-2.60 (m, 4 H) 2.32 (s, 3 H); MS m/z (M+H) 340.

Provenance & Evidence