反应详情

温度

100 °C

In a microwave vial were added 2-(6-fluoropyridin-3-yl)-6-methoxy-1,3-benzothiazole (75 mg, 0.289 mmol), water (2.0 mL) and ethylmethylamine (0.50 mL) and the reaction was heated in a microwave oven at 100° C. for 5 min. The precipitated product was filtered off, washed with water and dried in a desicator over P2O5 to yield the product (70 mg) as a beige solid. 1H NMR δ ppm 8.71 (d, 1 H) 8.06 (dd, 2.53 Hz, 1 H) 7.85 (d, 1 H) 7.66 (d, 1H) 7.08 (dd, 1 H) 6.76 (d, 1 H) 3.84 (s, 3 H) 3.64 (q, 2 H) 3.08 (s, 3 H) 1.12 (t, 3 H); MS m/z (M+H) 300.

1. filtrationThe precipitated product was filtered off
2. washwashed with water
3. dry with materialdried in a desicator over P2O5