2-Bromo-1,3-benzothiazole → 5-(5-methoxy-1,3-benzothiazol-2-yl)-N-methylpyridin-2-amine

Participants

Reaction Steps

2-Bromo-1,3-benzothiazole (100 mg, 0.47 mmol) and 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]morpholine (163 mg, 0.56 mmol) were reacted according to the procedure used for the preparation of 5-(6-methoxy-1,3-benzothiazol-2-yl)pyrimidin-2-amine. Flash chromatography (Heptane/EtOAc 1:1) furnished the title compound (73 mg) as an off-white solid. 1H NMR δ 8.81 (d, 1 H) 8.18 (dd, 1 H) 8.10 (d, 1H) 7.98 (d, 1 H) 7.54-7.48 (m, 1 H) 7.44-7.38 (m, 1 H) 7.00 (d, 1 H) 3.74-3.70 (m, 4 H) 3.65-3.60 (m, 4 H); MS m/z (M+H) 298.

Provenance & Evidence