Ethyl Acetate → N-[[1-[[(4-Methoxyphenyl)carbonyl]amino]cyclohexyl]carbonyl]-L-valinol

HRID 1851862노트

반응식

HRID 1851862 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2C(=O)[C:12](=[O:15])[C:11]3([CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[N:10]=2)=[CH:5][CH:4]=1.[NH2:21][C@H:22]([CH2:26][OH:27])[CH:23]([CH3:25])[CH3:24].C(OCC)(=[O:30])C>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]([NH:10][C:11]2([C:12]([NH:21][C@H:22]([CH2:26][OH:27])[CH:23]([CH3:25])[CH3:24])=[O:15])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:30])=[CH:7][CH:8]=1

참가 물질

4

반응물 3

HCID 8857Ethyl AcetateHCID 640993L-ValinolHCID 671816222-(4-Methoxyphenyl)-3-oxo-1-azaspiro[4.5]dec-1-en-4-one

생성물 1

HCID 24875901N-[[1-[[(4-Methoxyphenyl)carbonyl]amino]cyclohexyl]carbonyl]-L-valinol수율 66.7%

실험 절차

260 mg (1.00 mmol) of 2-(4-methoxyphenyl)-3-oxo-1-azaspiro[4.5]dec-1-en-4-one was added to a solution of 252 mg (2.45 mmol) of L-valinol in 5 ml of ethyl acetate, and the mixture was stirred at room temperature for 4 days. The reaction solution was distilled off under reduced pressure and the residue was washed with diethyl ether to obtain 243.5 mg (66.7%) of the title compound.

후처리

  1. distillationThe reaction solution was distilled off under reduced pressure
  2. washthe residue was washed with diethyl ether

출처 및 근거

ORD 기록
ord-f5cc03dffa2e42bbb215e852fa8174db
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957205B2

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