1-Phenylpropan-1-amine → HCID 49852647, compound

HRID 1851887Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]2[C:24]3[C:19](=[CH:20][C:21]([C:25]([OH:27])=O)=[CH:22][CH:23]=3)[C:18]([CH3:28])=[C:17]2[CH3:29])=[CH:11][CH:10]=1)#[N:2].[C:30]1([CH:36]([NH2:39])[CH2:37][CH3:38])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]2[C:24]3[C:19](=[CH:20][C:21]([C:25]([NH:39][CH:36]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH2:37][CH3:38])=[O:27])=[CH:22][CH:23]=3)[C:18]([CH3:28])=[C:17]2[CH3:29])=[CH:11][CH:10]=1)#[N:2]

Participants

Reactant 2

HCID 180541-Phenylpropan-1-amine

HCID 49852640HCID 49852640, compound

Product 1

HCID 49852647HCID 49852647, compound

Procedure

The title compound was prepared following the same protocol as described in Step 8, Example 1, using 1-((2′-cyano-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-((2′-(tert-butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid, and 1-phenylpropan-1-amine instead of the (S)-1-(4-bromophenyl)ethanamine. ESI-MS (m/z): 498 [M+H]+.

Sources & evidence

ORD record: ord-36a495ed57564ce18682c94f1a25dc73
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957093B2

Reaction notes

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