(S)-1-(4-Fluorophenyl)-ethylamine → HCID 71074707, compound

HRID 1851934Notes

Reaction equation

HRID 1851934 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C@@H:6]([NH2:8])[CH3:7])=[CH:4][CH:3]=1.C([O:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]1[CH:29]=[CH:28][C:27]([CH2:30][N:31]2[C:39]3[C:34](=[CH:35][C:36]([C:40](O)=[O:41])=[CH:37][CH:38]=3)[C:33]([CH3:43])=[C:32]2[CH3:44])=[CH:26][CH:25]=1)=[O:17])(C)(C)C>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C@@H:6]([NH:8][C:40]([C:36]2[CH:35]=[C:34]3[C:39](=[CH:38][CH:37]=2)[N:31]([CH2:30][C:27]2[CH:26]=[CH:25][C:24]([C:19]4[C:18]([C:16]([OH:17])=[O:15])=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:29][CH:28]=2)[C:32]([CH3:44])=[C:33]3[CH3:43])=[O:41])[CH3:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2779063(S)-1-(4-Fluorophenyl)-ethylamineHCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid

Product 1

HCID 71074707HCID 71074707, compound

Procedure

The title compound was prepared following the same general protocol as described in Steps 8-9, Example 1, using 4-fluoro-α-(S)-methylbenzylamine and 1-((2′-(tert-butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. LC-MS 521 (M+H).

Sources & evidence

ORD record
ord-e8ad7ea0488a429492487db82c36fbdf
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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