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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1851943Generated: October 27, 2026

(3-Ethoxycarbonylphenyl)boronic acid → 1-((3'-(Ethoxycarbonyl)-[1,1'-biphenyl]-2-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid

https://huagongshe.com/reaction/1851943

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Ethoxycarbonylphenyl)boronic acidHCID 3249312—
Reactant1-(2-Bromobenzyl)-2,3-dimethyl-1H-indole-5-carboxylic acidHCID 71074806—
Product1-((3'-(Ethoxycarbonyl)-[1,1'-biphenyl]-2-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acidHCID 71074535—

Reaction Steps

The title compound was prepared following the same protocol as described in Step 5, Example 38, using 1-(2-bromobenzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the (S)-1-(4-bromobenzyl)-N-(1-(4-nitrophenyl)ethyl)-1H-indole-5-carboxamide and the (3-(ethoxycarbonyl)phenyl)boronic acid instead of the phenylboronic acid. ESI-MS (m/z): 428 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08957093B2
Source datasetuspto-grants-2015_02
ORD IDord-c114e2b10b38478d8bd3a2b77b4dd04c
Source noteuspto-grants-2015_02