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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1851948Generated: October 27, 2026

1-Phenylpropan-1-amine → Ethyl 2'-((2,3-dimethyl-5-((1-phenylpropyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylate

https://huagongshe.com/reaction/1851948

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Phenylpropan-1-amineHCID 18054—
Reactant1-((4'-(Ethoxycarbonyl)-[1,1'-biphenyl]-2-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acidHCID 71074347—
ProductEthyl 2'-((2,3-dimethyl-5-((1-phenylpropyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylateHCID 71074868—

Reaction Steps

The title compound was prepared following the same protocol as described in Step 8, Example 1, using the 1-((4′-(ethoxycarbonyl)-[1,1′-biphenyl]-2-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of the 1-((2′-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid and the 1-phenylpropan-1-amine instead of the (S)-1-(4-bromophenyl)ethanamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08957093B2
Source datasetuspto-grants-2015_02
ORD IDord-0ff16a8859cf4605b142e699ef30d574
Source noteuspto-grants-2015_02