1H-Indole-5-Carboxylic Acid → HCID 71074666, compound

HRID 1851949Notes

Reaction equation

HRID 1851949 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Br[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[C:22]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:17][CH:16]=1>>[C:30]([O:29][C:27]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[C:18]1[CH:19]=[CH:20][C:15]([CH2:14][N:1]2[C:9]3[C:4](=[CH:5][C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=3)[CH:3]=[CH:2]2)=[CH:16][CH:17]=1)=[O:28])([CH3:33])([CH3:32])[CH3:31]

Participants

3

Reactant 2

HCID 742801H-Indole-5-Carboxylic AcidHCID 9906257tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate

Product 1

HCID 71074666HCID 71074666, compound

Procedure

The title compound was prepared following the same protocol as described in Step 2, Example 38, using 1H-indole-5-carboxylic acid instead of the methyl 1H-indole-5-carboxylate, and the tert-butyl 4′-(bromomethyl)biphenyl-2-carboxylate instead of the 1-bromo-4-(bromomethyl)benzene. ESI-MS (m/z): 428 [M+H]+.

Sources & evidence

ORD record
ord-7a3e39f2b5434146bd69664f9a89d5a6
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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