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HRID 1851955作成日:2026年10月25日

(1S)-1-(4-Nitrophenyl)ethan-1-amine → (S)-tert-Butyl 4'-((5-((1-(4-nitrophenyl)ethyl)carbamoyl)-3-methyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

https://huagongshe.com/reaction/1851955

反応式

関与物質

役割名称HCID仕込み量
反応物(1S)-1-(4-Nitrophenyl)ethan-1-amineHCID 1268055—
反応物1-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-3-methyl-1H-indole-5-carboxylic acidHCID 71074350—
生成物(S)-tert-Butyl 4'-((5-((1-(4-nitrophenyl)ethyl)carbamoyl)-3-methyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylateHCID 86674544—

反応手順

The title compound was prepared following the same protocol as described in Step 8, Example 1, using the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-3-methyl-1H-indole-5-carboxylic acid instead of the 1-((2′-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid and the (S)-1-(4-nitrophenyl)ethanamine instead of the (S)-1-(4-bromophenyl)ethanamine.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08957093B2
出典データセットuspto-grants-2015_02
ORD IDord-2812cb7c76c74812956c0cae665834ac
出典メモuspto-grants-2015_02