tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate → HCID 71074944, compound

HRID 1851956Notes

Reaction equation

HRID 1851956 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:5]=2.Br[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[C:24]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[CH:25][CH:26]=[CH:27][CH:28]=2)=[CH:19][CH:18]=1>>[C:32]([O:31][C:29]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:20]1[CH:21]=[CH:22][C:17]([CH2:16][N:3]2[C:4]3[C:9](=[CH:8][C:7]([C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])=[CH:18][CH:19]=1)=[O:30])([CH3:35])([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 9906257tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylateHCID 12230324HCID 12230324, compound

Product 1

HCID 71074944HCID 71074944, compound

Procedure

The title compound was prepared following the same protocol as described in Step 2, Example 38, using the methyl 2-methyl-1H-indole-5-carboxylate instead of the methyl 1H-indole-5-carboxylate, and the tert-butyl 4′-(bromomethyl)biphenyl-2-carboxylate instead of the 1-bromo-4-(bromomethyl)benzene. ESI-MS (m/z): 456 [M+H]+.

Sources & evidence

ORD record
ord-bcc75b13142f40bc9ec111beca308e23
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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