1-Phenylpropan-1-amine → HCID 86674545, compound

HRID 1851957Notes

Reaction equation

HRID 1851957 reaction equation
[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:29]3[C:24](=[CH:25][C:26]([C:30](O)=[O:31])=[CH:27][CH:28]=3)[CH:23]=[C:22]2[CH3:33])=[CH:16][CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:34]1([CH:40]([NH2:43])[CH2:41][CH3:42])[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH3:33][C:22]1[N:21]([CH2:20][C:17]2[CH:18]=[CH:19][C:14]([C:9]3[C:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[CH:13][CH:12]=[CH:11][CH:10]=3)=[CH:15][CH:16]=2)[C:29]2[C:24]([CH:23]=1)=[CH:25][C:26]([C:30](=[O:31])[NH:43][CH:40]([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH2:41][CH3:42])=[CH:27][CH:28]=2

Participants

3

Reactant 2

HCID 180541-Phenylpropan-1-amineHCID 71074604HCID 71074604, compound

Product 1

HCID 86674545HCID 86674545, compound

Procedure

The title compound was prepared following the same protocol as described in Step 8, Example 1, using the 1-((2′-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2-methyl-1H-indole-5-carboxylic acid instead of the 1-((2′-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid and the 1-phenylpropan-1-amine instead of the (S)-1-(4-bromophenyl)ethanamine.

Sources & evidence

ORD record
ord-022f404600fa42ec91970a238ed970e2
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

Loading…