HCID 56971836, compound → HCID 53481925, compound

HRID 1851963Notes

Reaction equation

HRID 1851963 reaction equation
[F:1][C:2]([F:15])([F:14])[C@@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]([CH3:13])[CH3:12])[CH:6]=1)[NH2:4].C([O:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N:36]2[C:44]3[C:39](=[CH:40][C:41]([C:45](O)=[O:46])=[CH:42][CH:43]=3)[C:38]([CH3:48])=[C:37]2[CH3:49])=[CH:31][CH:30]=1)=[O:22])(C)(C)C>>[CH3:49][C:37]1[N:36]([CH2:35][C:32]2[CH:33]=[CH:34][C:29]([C:24]3[C:23]([C:21]([OH:22])=[O:20])=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:30][CH:31]=2)[C:44]2[C:39]([C:38]=1[CH3:48])=[CH:40][C:41]([C:45](=[O:46])[NH:4][C@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]([CH3:13])[CH3:12])[CH:6]=1)[C:2]([F:14])([F:15])[F:1])=[CH:42][CH:43]=2

Participants

3

Reactant 2

HCID 56971836HCID 56971836, compoundHCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid

Product 1

HCID 53481925HCID 53481925, compound

Procedure

The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using (R)-2,2,2-trifluoro-1-(3-isopropylphenyl)ethanamine and 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 599 [M+H]+.

Sources & evidence

ORD record
ord-6f268a82961d4d4485c36660833a2b5d
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

Loading…