1-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid → HCID 54579806, compound

HRID 1851967Notes

Reaction equation

HRID 1851967 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C@@H:10]([NH2:12])[CH3:11])[C:4]=2[O:3][CH2:2]1.C([O:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29]([CH2:32][N:33]2[C:41]3[C:36](=[CH:37][C:38]([C:42](O)=[O:43])=[CH:39][CH:40]=3)[C:35]([CH3:45])=[C:34]2[CH3:46])=[CH:28][CH:27]=1)=[O:19])(C)(C)C>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C@@H:10]([NH:12][C:42]([C:38]3[CH:37]=[C:36]4[C:41](=[CH:40][CH:39]=3)[N:33]([CH2:32][C:29]3[CH:28]=[CH:27][C:26]([C:21]5[C:20]([C:18]([OH:19])=[O:17])=[CH:25][CH:24]=[CH:23][CH:22]=5)=[CH:31][CH:30]=3)[C:34]([CH3:46])=[C:35]4[CH3:45])=[O:43])[CH3:11])[C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acidHCID 86674549HCID 86674549, compound

Product 1

HCID 54579806HCID 54579806, compound

Procedure

The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using (S)-1-(benzo[d][1,3]dioxol-4-yl)ethanamine and 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 547 [M+H]+.

Sources & evidence

ORD record
ord-8f9de8ee83424c7cbdec37fedd5378e6
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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