(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine → HCID 53389254, compound

HRID 1851977Notes

Reaction equation

HRID 1851977 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]([NH2:12])[CH3:11])=[CH:6][CH:5]=1.C([O:19][C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[C:28]1[CH:33]=[CH:32][C:31]([CH2:34][N:35]2[C:43]3[C:38](=[CH:39][C:40]([C:44](O)=[O:45])=[CH:41][CH:42]=3)[C:37]([CH3:47])=[C:36]2[CH3:48])=[CH:30][CH:29]=1)=[O:21])(C)(C)C>>[CH3:48][C:36]1[N:35]([CH2:34][C:31]2[CH:32]=[CH:33][C:28]([C:23]3[C:22]([C:20]([OH:21])=[O:19])=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:29][CH:30]=2)[C:43]2[C:38]([C:37]=1[CH3:47])=[CH:39][C:40]([C:44](=[O:45])[NH:12][C@H:10]([C:7]1[CH:6]=[CH:5][C:4]([O:3][C:2]([F:13])([F:14])[F:1])=[CH:9][CH:8]=1)[CH3:11])=[CH:41][CH:42]=2

Participants

3

Reactant 2

HCID 40786949(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamineHCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid

Product 1

HCID 53389254HCID 53389254, compound

Procedure

The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using the (S)-1-(4-(trifluoromethoxy)phenyl)ethanamine and the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 587 [M+H]+.

Sources & evidence

ORD record
ord-77408a7ceb3d4709ac79b01d33ebd5eb
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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