HRID1851989

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2737566

2-Fluoro-4-(trifluoromethyl)benzylamine

C8H7F4N

结构：Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)OC(C)(C)C)cc2)c2ccc(C(=O)O)cc12

HCID71074664

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c2ccc(C(=O)NCc3ccc(C(F)(F)F)cc3F)cc12

HCID53361999

未命名化合物

PROCEDURE

实验过程

The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using the (2-fluoro-4-(trifluoromethyl)phenyl)methanamine and the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 575 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-53be6ab64f5b4434ac07da8a28dd63f8
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08957093B2
来源说明: uspto-grants-2015_02

反应 SMILES

[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][NH2:13].C([O:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH:32]=[CH:31][C:30]([CH2:33][N:34]2[C:42]3[C:37](=[CH:38][C:39]([C:43](O)=[O:44])=[CH:40][CH:41]=3)[C:36]([CH3:46])=[C:35]2[CH3:47])=[CH:29][CH:28]=1)=[O:20])(C)(C)C>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][NH:13][C:43]([C:39]1[CH:38]=[C:37]2[C:42](=[CH:41][CH:40]=1)[N:34]([CH2:33][C:30]1[CH:29]=[CH:28][C:27]([C:22]3[C:21]([C:19]([OH:20])=[O:18])=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:32][CH:31]=1)[C:35]([CH3:47])=[C:36]2[CH3:46])=[O:44]