2-Fluoro-4-(trifluoromethyl)benzylamine → 4'-((5-((2-fluoro-4-(trifluoromethyl)benzyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][NH2:13].C([O:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH:32]=[CH:31][C:30]([CH2:33][N:34]2[C:42]3[C:37](=[CH:38][C:39]([C:43](O)=[O:44])=[CH:40][CH:41]=3)[C:36]([CH3:46])=[C:35]2[CH3:47])=[CH:29][CH:28]=1)=[O:20])(C)(C)C>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][NH:13][C:43]([C:39]1[CH:38]=[C:37]2[C:42](=[CH:41][CH:40]=1)[N:34]([CH2:33][C:30]1[CH:29]=[CH:28][C:27]([C:22]3[C:21]([C:19]([OH:20])=[O:18])=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:32][CH:31]=1)[C:35]([CH3:47])=[C:36]2[CH3:46])=[O:44]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using the (2-fluoro-4-(trifluoromethyl)phenyl)methanamine and the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 575 [M+H]+.
Sources & evidence
- ORD record
- ord-53be6ab64f5b4434ac07da8a28dd63f8
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08957093B2
Reaction notes
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