HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-1-[3-(Trifluoromethyl)phenyl]ethylamine → (S)-4'-((2,3-dimethyl-5-((1-(3-(trifluoromethyl)phenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-1-[3-(Trifluoromethyl)phenyl]ethylamine | HCID 7023585 | — |
| Reactant | 1-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid | HCID 71074664 | — |
| Product | (S)-4'-((2,3-dimethyl-5-((1-(3-(trifluoromethyl)phenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid | HCID 53389239 | — |
Reaction Steps
The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using the (S)-1-(3-(trifluoromethyl)phenyl)ethanamine and the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 571 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957093B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-3f8ab543329c48b3abf649e5c4ca9c02 |
| Source note | uspto-grants-2015_02 |