1-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid → HCID 53481933, compound

HRID 1852005Notes

Reaction equation

HRID 1852005 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C@@H:10]([NH2:18])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2].C([O:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:32]1[CH:37]=[CH:36][C:35]([CH2:38][N:39]2[C:47]3[C:42](=[CH:43][C:44]([C:48](O)=[O:49])=[CH:45][CH:46]=3)[C:41]([CH3:51])=[C:40]2[CH3:52])=[CH:34][CH:33]=1)=[O:25])(C)(C)C>>[CH:1]([C:4]1[CH:5]=[C:6]([C@@H:10]([NH:18][C:48]([C:44]2[CH:43]=[C:42]3[C:47](=[CH:46][CH:45]=2)[N:39]([CH2:38][C:35]2[CH:34]=[CH:33][C:32]([C:27]4[C:26]([C:24]([OH:25])=[O:23])=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:37][CH:36]=2)[C:40]([CH3:52])=[C:41]3[CH3:51])=[O:49])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acidHCID 71075116HCID 71075116, compound

Product 1

HCID 53481933HCID 53481933, compound

Procedure

The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using the (S)-1-(3-isopropylphenyl)-2-phenylethanamine and the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 587 [M+H]+.

Sources & evidence

ORD record
ord-248dad5129e6470583edd8e365db6536
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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