1-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid → HCID 54669705, compound

HRID 1852011Notes

Reaction equation

HRID 1852011 reaction equation
[Cl-].[CH2:2]([O:9][C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C@@H:18]([NH3+:20])[CH3:19])[CH2:14][CH2:13]1)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C([O:25][C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[C:34]1[CH:39]=[CH:38][C:37]([CH2:40][N:41]2[C:49]3[C:44](=[CH:45][C:46]([C:50](O)=[O:51])=[CH:47][CH:48]=3)[C:43]([CH3:53])=[C:42]2[CH3:54])=[CH:36][CH:35]=1)=[O:27])(C)(C)C>>[CH2:2]([O:9][C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C@@H:18]([NH:20][C:50]([C:46]2[CH:45]=[C:44]3[C:49](=[CH:48][CH:47]=2)[N:41]([CH2:40][C:37]2[CH:36]=[CH:35][C:34]([C:29]4[C:28]([C:26]([OH:27])=[O:25])=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:39][CH:38]=2)[C:42]([CH3:54])=[C:43]3[CH3:53])=[O:51])[CH3:19])[CH2:14][CH2:13]1)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acidHCID 71074722HCID 71074722, compound

Product 1

HCID 54669705HCID 54669705, compound

Procedure

The title compound was prepared following the same general synthetic procedure as described in Steps 3-4, Example 2, starting with ((S)-1-(1-((benzyloxy)carbonyl)piperidin-4-yl)ethanaminium chloride and 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid instead of (S)-1-(4-(tert-butyl)phenyl)ethanaminium chloride and 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-H-indole-5-carboxylic acid. ESI-MS (m/z): 643 [M+1]+.

Sources & evidence

ORD record
ord-5612ff5a9879425fb1f831b0f657be46
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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