(S)-1-(3,4-DIFLUOROPHENYL)ETHANAMINE-HCl → HCID 71075228, compound

HRID 1852021Notes

Reaction equation

HRID 1852021 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([C@@H:10]([NH2:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9].C([O:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29]([CH2:32][N:33]2[C:41]3[C:36](=[CH:37][C:38]([C:42](O)=[O:43])=[CH:39][CH:40]=3)[C:35]([CH3:45])=[C:34]2[CH3:46])=[CH:28][CH:27]=1)=[O:19])(C)(C)C>>[F:2][C:3]1[CH:4]=[C:5]([C@@H:10]([NH:12][C:42]([C:38]2[CH:37]=[C:36]3[C:41](=[CH:40][CH:39]=2)[N:33]([CH2:32][C:29]2[CH:28]=[CH:27][C:26]([C:21]4[C:20]([C:18]([OH:19])=[O:17])=[CH:25][CH:24]=[CH:23][CH:22]=4)=[CH:31][CH:30]=2)[C:34]([CH3:46])=[C:35]3[CH3:45])=[O:43])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9]

Participants

3

Reactant 2

HCID 45072356(S)-1-(3,4-DIFLUOROPHENYL)ETHANAMINE-HClHCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid

Product 1

HCID 71075228HCID 71075228, compound

Procedure

The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using the (S)-1-(3,4-difluorophenyl)ethanamine hydrochloride and the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 539 [M+H]+.

Sources & evidence

ORD record
ord-13d9a7a6e9594a59bde8db434ad9456c
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

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