1-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid → HCID 71074668, compound

HRID 1852028Notes

Reaction equation

HRID 1852028 reaction equation
Cl.[NH2:2][C@H:3]([C@@H:5]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])[CH2:6]1)[CH3:4].C([O:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33]1[CH:38]=[CH:37][C:36]([CH2:39][N:40]2[C:48]3[C:43](=[CH:44][C:45]([C:49](O)=[O:50])=[CH:46][CH:47]=3)[C:42]([CH3:52])=[C:41]2[CH3:53])=[CH:35][CH:34]=1)=[O:26])(C)(C)C>>[CH2:13]([O:12][C:10]([N:7]1[CH2:8][CH2:9][C@@H:5]([C@@H:3]([NH:2][C:49]([C:45]2[CH:44]=[C:43]3[C:48](=[CH:47][CH:46]=2)[N:40]([CH2:39][C:36]2[CH:35]=[CH:34][C:33]([C:28]4[C:27]([C:25]([OH:26])=[O:24])=[CH:32][CH:31]=[CH:30][CH:29]=4)=[CH:38][CH:37]=2)[C:41]([CH3:53])=[C:42]3[CH3:52])=[O:50])[CH3:4])[CH2:6]1)=[O:11])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 710746641-((2'-(tert-Butoxycarbonyl)biphenyl-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acidHCID 86674567HCID 86674567, compound

Product 1

HCID 71074668HCID 71074668, compound

Procedure

The title compound was prepared following the same general protocol as described in Step 8-9, Example 1, using the (R)-benzyl 3-((S)-1-aminoethyl)pyrrolidine-1-carboxylate hydrochloride and the 1-((2′-(tert-butoxycarbonyl)-[1,1′-biphenyl]-4-yl)methyl)-2,3-dimethyl-1H-indole-5-carboxylic acid. ESI-MS (m/z): 630 [M+H]+.

Sources & evidence

ORD record
ord-6ddc4836743d42bdbcbfe8857816dc49
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

Loading…