Potassium Phosphate, Tribasic → HCID 71074710, compound

Participants

Reaction Conditions

Reaction Steps

A high-pressure vial was filled with the (S)-tert-butyl 4′-((5-((1-(5-bromopyridin-2-yl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1′-biphenyl]-2-carboxylate (50 mg, 0.078 mmol), cyclopropylboronic acid (8 mg, 0.09 mmol, 1.2 equiv), Pd(OAc)2 (12 mg, 0.055 mmol, 0.7 equiv), (Cy)3P (8.7 mg, 0.031 mmol, 0.4 equiv), K3PO4 (49 mg, 0.23 mmol, 3 equiv), in toluene-water (10%). The reaction mixture was heated at 100° C. for 3 h under microwaves. The mixture was evaporated in vacuo to obtain the crude which was purified by prep. HPLC (MeOH/Acetonitrile/water) to obtain the title compound.

Provenance & Evidence