Potassium Carbonate → HCID 71099679, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-tert-butyl 4′-((5-((1-(3-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1′-biphenyl]-2-carboxylate (24 mg, 0.038 mmol), trimethylboroxine (10 μL, 0.072 mmol), Pd(PPh3)4 (11 mg, 0.0095 mmol) and K2CO3 (15 mg, 0.11 mmol) in Dioxane (0.7 ml) were heated in a Biotage Microwave reactor at 100° C. for 2 h. The solvent was removed and the residue was purified by reverse phase prep-HPLC (MeOH/Acetonitrile/water) to obtain the title compound.

Provenance & Evidence