HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (2E)-3-(4-Fluoro-2-methoxyphenyl)-2-propenoyl azide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | (2E)-3-(4-Fluoro-2-methoxyphenyl)-2-propenoic acid | HCID 23150778 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | (2E)-3-(4-Fluoro-2-methoxyphenyl)-2-propenoyl azide | HCID 86683195 | 76.5% |
Reaction Steps
(E)-3-(4-fluoro-2-methoxyphenyl)acrylic acid (1.22 g, 6.22 mmol), diphenylphosphinyl azide (1.273 mL, 5.91 mmol), and Et3N (1.734 mL, 12.44 mmol) were dissolved in benzene and stirred for 16 h. The solution was concentrated under vacuum and the residue was purified by silica gel chromatography using 20% EtOAc/Hexanes to give (E)-3-(4-fluoro-2-methoxyphenyl)acryloyl azide (1.0 g, 73% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957203B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d2d1140c6ef54b398004eff84696f3c1 |
| Source note | uspto-grants-2015_02 |