Dimethylamine → HCID 70978361, compound

HRID 1852271Notes

Reaction equation

HRID 1852271 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5](=[O:14])[NH:4][CH:3]=1.[CH3:15][NH:16][CH3:17]>>[CH3:15][N:16]([CH3:17])[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5](=[O:14])[NH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 579564624-Bromo-6-methoxyisoquinolin-1(2H)-one

Product 1

HCID 70978361HCID 70978361, compoundYield 116.2%

Procedure

A solution of 4-bromo-6-methoxyisoquinolin-1(2H)-one (1 g, 3.94 mmol) in dimethylamine (5 ml, 39.5 mmol) was heated to 105° C. for 48 h. After cooling, the reaction mixture was concentrated under reduced pressure to get 4-(Dimethylamino)-6-methoxyisoquinolin-1(2H)-one (0.8 g, 4.58 mmol, 85% yield). MS: MS m/z 219.20 (M++1).

Workup

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-644c4ba85e754b3b8f64bad0b14b3bde
Source dataset
uspto-grants-2015_02
Patent number
US08957203B2

Reaction notes

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