Sodium Hydroxide → potassium sodium D-glucarate

Aqueous sodium hydroxide solution (21 mL, 2 M) was added to a slurry of monopotassium D-glucarate (10.0 g, 40.3 mmol) in water (50 mL) until all of the solid dissolved and a constant pH of 10 was reached. The volume of the solution was reduced to 20 mL by rotary evaporator. Methanol (15 mL) was added, producing a cloudy solution which cleared upon heating. The solution was allowed to sit undisturbed at 5° C. Crystals grew from the solution over a 48 h period. The crystals were isolated by filtration, washed with cold 1:1 methanol/water (3×5 mL), and dried under reduced pressure to give sodium potassium D-glucarate as colorless crystals (10.2 g, 33.2 mmol as the dihydrate, 82.4%).

1. dissolutiondissolved
2. customThe volume of the solution was reduced to 20 mL by rotary evaporator
3. additionMethanol (15 mL) was added
4. customproducing a cloudy solution which
5. temperatureupon heating
6. customto sit undisturbed at 5° C
7. customThe crystals were isolated by filtration
8. washwashed with cold 1:1 methanol/water (3×5 mL)
9. customdried under reduced pressure

ORD record

ord-bb984476eea0498ba07857a8e627f37c

Source dataset

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08961813B2