Putrescine → 3-((4-Aminobutyl)amino)propanenitrile

Participants

Reaction Steps

Acrylonitrile (5.08 g, 0.096 mol) was added to ice bath-cooled 1,4-butanediamine (8.44 g, 0.096 mol) in 30 min. The resulting mixture was stirred for 2 h at RT, heated to 50° C. for further 3 h and finally let stirring at RT overnight. After Kugelrohr distillation colourless oil was obtained (5.80 g, 0.041 mol, yield 42.8%).

Provenance & Evidence