HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propyne, 3-fluoro- → HCID 46183000, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propyne, 3-fluoro- | HCID 137718 | — |
| Reactant | L-Ascorbic Acid | HCID 54670067 | — |
| Reactant | HCID 131732460 | HCID 131732460 | — |
| Catalyst | Copper Sulfate | HCID 24462 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 46183000 | HCID 46183000 | — |
Reaction Steps
is prepared as illustrated in FIG. 2(ii), by reaction of (S)-1-(azidomethyl)-5-(2-(2,4-difluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin] (compound 37) with 3-fluoroprop-1-yne (compound 28). The reagents are as follows: (a) CuSO4, L-ascorbic acid, DMF. For the preparation of [18F]6, 3-[18F]fluoroprop-1-yne is used in place of 3-fluoroprop-1-yne.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08961930B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-334e9ccc6e6844029e81565ed06cf1e9 |
| Source note | uspto-grants-2015_02 |