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HRID1852349

反应详情

EQUATION

反应方程式

HRID 1852349 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1
HCID6436

Triamcinolone acetonide

C24H31FO6

结构：C[C@]12C=CC(=O)C=C1[C@@H](F)C[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F
HCID91488

Fluocinolone

C21H26F2O6

PRODUCTS

生成物

1
结构：C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F
HCID31307

Triamcinolone

C21H27FO6

PROCEDURE

实验过程

Triamcinolone acetonide was combined with a polymer in a stainless steel mortar and mixed using the Turbula shaker set at 96 RPM for 15 minutes. The powder of the fluocinolone and polymer was scraped off the walls of the steel mortar and then mixed again for an additional 15 minutes. The powder blend was heated at temperatures ranging from 110° C. to 160° C., depending on the polymer used, for a total of 30 minutes, forming a polymer/drug melt. The melt was pelletized, then loaded into the barrel and extruded into filaments, and finally the filaments were cut into about 0.5 mg or about 1 mg size implants. The implants had a weight range from about 450 μg to about 550 μg, or from about 900 μg to about 1100 μg. The 1 mg size implants had a length of about 2 mm and a diameter of about 0.72 mm.

WORKUP

后处理

  1. additionmixed
  2. additionmixed again for an additional 15 minutes
  3. temperatureThe powder blend was heated at temperatures
  4. customranging from 110° C. to 160° C.
  5. customused, for a total of 30 minutes
  6. customforming a polymer/drug