4-Methyl-1-nitro-2-[2-(2-nitrophenoxy)ethoxy]benzene → 2-[2-(2-Aminophenoxy)ethoxy]-4-methylaniline

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Reaction Steps

100 g 4-methyl-1-nitro-2-(2-(2-nitro-phenoxy)-ethoxy)-benzene and 10 g palladium on charcoal were suspended in 3.5 l dioxane and hydrogenated at room temperature under a hydrogen pressure of 5.5 bar. After flashing three times with nitrogen the catalyst was filtered off under a nitrogen atmosphere and the remaining solution was evaporated and the product was dried under vacuum. Yield: 80 g.

Provenance & Evidence