Trifluoroacetic acid → HCID 67073703, compound

Participants

Reaction Steps

1.19 g of tert-butyl(3-{2-[(cyclopropylsulfonyl)amino]-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate (1.8 mmol, 1 eq.) were dissolved in 15 mL DCM, treated with 2 mL TFA and stirred at rt for 6 h. The reaction mixture was cooled to 0° C. and adjusted with 1N Sodium hydroxide to pH 10. The layers were separated, the aqueous layer was reextracted with DCM. The combined organic layers were dried, filtered and concentrated in vacuo to yield 776 mg of the crude product (77% yield), which was used without further purification.

Provenance & Evidence