4-Piperidinecarboxamide → HCID 56646022, compound

Participants

Reaction Steps

A stirred solution of N-{5-[4-(3-Cyano-4-fluoro-phenyl)-pyrimidin-2-ylamino]-pyridin-2-yl}-acetamide (100 mg, 0.28 mmol) and piperidine-4-carboxylic acid amide in n-butanol (5 mL) was heated to 115° C. in a sealed tube for 48 h. The solvent was evaporated to obtain the crude compound. The crude compound was purified by preparative-HPLC to obtain the desired product as pale yellow powder (38 mg, 29%); LC-MS, Rt,=2.96 min (Method C), m/z 457 (MH+). In addition to this procedure similar reactions may also be accomplished at 110° for 16-120 h. Purification may be by preparative-HPLC or flash column chromatography.

Provenance & Evidence