Nitrogen → 6-Oxospiro[2.5]octane-5-carbonitrile

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Reaction Steps

6-Oxospiro[2.5]oct-4-ene-5-carbonitrile (0.16 g, 1.1 mmol) was dissolved in MeOH (11 mL) and combined with 10% palladium on activated carbon (0.12 g, 0.11 mmol). The resulting mixture was subjected to alternating vacuum and H2 gas (4×). The mixture was then stirred under an atmosphere of H2 (50 psi) for 16 hours. The mixture was then subjected to alternating vacuum and N2 gas (4×). The mixture was filtered through celite and rinsed with MeOH. The filtrate was concentrated in vacuo to afford the title compound. The material was used without further purification.

Provenance & Evidence