HCID 89585288, compound → HCID 89585285, compound

HRID 1852499Notes

Reaction equation

HRID 1852499 reaction equation
[Na].[NH:2]1[C:6]([C:7]2[CH:8]=[C:9]([N:13]3[C:19](=[O:20])[CH2:18][C:17](=[O:21])[NH:16][C:15]4[C:22]5[CH2:23][CH2:24][CH2:25][CH2:26][C:27]=5[CH:28]=[CH:29][C:14]3=4)[CH:10]=[CH:11][CH:12]=2)=[N:5][N:4]=[N:3]1.[CH3:30]N1C(C2C=C(N3C(=O)CC(=O)NC4C5CCCCC=5C=CC3=4)C=CC=2)=NN=N1>>[CH3:30][N:4]1[N:3]=[N:2][C:6]([C:7]2[CH:8]=[C:9]([N:13]3[C:19](=[O:20])[CH2:18][C:17](=[O:21])[NH:16][C:15]4[C:22]5[CH2:23][CH2:24][CH2:25][CH2:26][C:27]=5[CH:28]=[CH:29][C:14]3=4)[CH:10]=[CH:11][CH:12]=2)=[N:5]1

Participants

3

Reactant 2

HCID 89585288HCID 89585288, compoundHCID 178516632HCID 178516632, compound

Product 1

HCID 89585285HCID 89585285, compound

Procedure

5-[3-(1H-Tetrazol-5-yl)phenyl]-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione sodium salt (40 mg, 0.10 mmol) obtained in Example 2 was used in a process similar to Example 6 to give 5-[3-(2-methyl-2H-tetrazol-5-yl)phenyl]-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione as slightly brown crystal (18 mg, yield 46%) and 5-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione as slightly brown crystal (3 mg, yield 8%).

Sources & evidence

ORD record
ord-d6031934389d4ad9b59933d102e3c883
Source dataset
uspto-grants-2015_02
Patent number
US08962613B2

Reaction notes

Loading…