Methyl iodide → N-[4-(2,4-Dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine-5-yl)phenyl]-N-methyl-2-nitrobenzenesulfonamide

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N-[4-(2,4-Dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepine-5-yl)phenyl]-2-nitrobenzenesulfonamide (150 mg, 0.3 mmol), methyl iodide (22 μL, 0.36 mmol), potassium carbonate (45 mg, 0.33 mmol), and dry dimethylformamide (3 mL) were mixed. The mixture was stirred at room temperature for 16 hours. The solvent was removed by evaporation under reduced pressure. To the residue was added water. The mixture was stirred at room temperature. Insoluble was obtained by filtration, washed with water, and air-dried overnight to give the titled compound as off-white crystal (112 mg, yield 73%).

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