HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-(Benzo[b]thiophen-3-yl)-3-chloropropan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Benzo(B)Thiophene | HCID 7221 | — |
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 1-(Benzo[b]thiophen-3-yl)-3-chloropropan-2-one | HCID 16100179 | 85.3% |
Reaction Steps
To the solution of benzothiophene (0.05 mol) dissolved in dichloromethane (30 mL), AlCl3 (0.10 mol) is added batch by batch and 3-chloropropionyl chloride (0.055 mol) is added dropwise, while the internal temperature is maintained below 5° C. Following procedures described in General Method One—Method A, 3-chloro-1-(benzothiophen-3- yl)-acetone is obtained as a white solid (9.6 g). The yield is 85.3%. MS(m/z): 225.0 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962621B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c1da22cab2d345e880e6133689856ae5 |
| Source note | uspto-grants-2015_02 |