Dichloromethane → HCID 86678628, compound

HRID 1852525Notes

Reaction equation

HRID 1852525 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.[Al+3].[Cl-].[Cl-].[Cl-].ClC[CH2:16][C:17](Cl)=[O:18].Cl[CH2:21][Cl:22]>>[Cl:22][CH2:21][C:17](=[O:18])[CH2:16][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 10329DihydrobenzofuranHCID 693643-Chloropropionyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 86678628HCID 86678628, compoundYield 80.2%

Procedure

To the solution of 2,3-dihydrobenzofuran (0.05 mol) dissolved in dichloromethane (30 mL), AlCl3 (0.10 mol) is added batch by batch and 3-chloropropionyl chloride (0.055 mol) is added dropwise, while the internal temperature is maintained below 5° C. Following procedures described in General Method One-Method A, 3-chloro-1-(2,3-dihydrobenzofuran-5-yl)-acetone is obtained as a white solid (8.4 g). The yield is 80.2%. MS(m/z): 211.0 [M+1]+.

Workup

  1. additionis added dropwise, while the internal temperature
  2. temperatureis maintained below 5° C

Sources & evidence

ORD record
ord-2bd91cb516564d15ad43ce05983b03a1
Source dataset
uspto-grants-2015_02
Patent number
US08962621B2

Reaction notes

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