HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 86678635, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Benzo(B)Thiophene | HCID 7221 | — |
| Reactant | 4-Chlorobutyryl chloride | HCID 78370 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | HCID 86678635 | HCID 86678635 | 79.8% |
Reaction Steps
To the solution of benzothiophene (0.05 mol) dissolved in dichloromethane (30 mL), AlCl3 (0.10 mol) is added batch by batch and 4-chlorobutanoyl chloride (0.055 mol) is added dropwise, while the internal temperature is maintained below 5° C. Following procedures described in General Method One-Method. A, 4-chloro-1-(benzothiophen-3-yl)-butanone is obtained as a white solid (9.5 g). The yield is 79.8%. MS(m/z): 239.0 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962621B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c706421bd2714c76acbe6bc88ddcc1d9 |
| Source note | uspto-grants-2015_02 |