Dichloromethane → HCID 21475938, compound

HRID 1852527Notes

Reaction equation

HRID 1852527 reaction equation
[CH2:1]1[O:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2]1.[Al+3].[Cl-].[Cl-].[Cl-].ClC[CH2:16][C:17](Cl)=[O:18].Cl[CH2:21][Cl:22]>>[Cl:22][CH2:21][C:17](=[O:18])[CH2:16][C:6]1[CH:7]=[CH:8][C:3]2[O:2][CH2:1][O:9][C:4]=2[CH:5]=1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 92291,3-BenzodioxoleHCID 693643-Chloropropionyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 21475938HCID 21475938, compoundYield 90%

Procedure

To the solution of 1,2-methylenedioxybenzene (0.05 mol) dissolved in dichloromethane (30 mL), AlCl3 (0.10 mol) is added batch by batch and 3-chloropropionyl chloride (0.055 mol) is added dropwise, while the internal temperature is maintained below 5° C. Following procedures described in General Method One-Method A, 3-chloro-1-(1,2-methylenedioxybenzen-4-yl)-propanone is obtained as a white solid (9.5 g). The yield is 90.0%. MS(m/z): 213.0 [M+1]+.

Workup

  1. additionis added dropwise, while the internal temperature
  2. temperatureis maintained below 5° C

Sources & evidence

ORD record
ord-3f26f7787cd34e38aab8b84580d0261c
Source dataset
uspto-grants-2015_02
Patent number
US08962621B2

Reaction notes

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