Dichloromethane → HCID 39247465, compound

HRID 1852528Notes

Reaction equation

HRID 1852528 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:10].[Al+3].[Cl-].[Cl-].[Cl-].ClC[CH2:17][C:18](Cl)=[O:19].Cl[CH2:22][Cl:23]>>[Cl:23][CH2:22][C:18](=[O:19])[CH2:17][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[C:4]([O:9][CH3:10])[CH:5]=1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 7043VeratroleHCID 693643-Chloropropionyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 39247465HCID 39247465, compoundYield 90%

Procedure

To the solution of 1,2-dimethoxybenzene (0.05 mol) dissolved in dichloromethane (30 mL), AlCl3 (0.10 mol) is added batch by batch and 3-chloropropionyl chloride (0.055 mol) is added dropwise, while the internal temperature is maintained below 5° C. Following procedures described in General Method One-Method A, 3-chloro-1-(3,4-dimethoxyphenyl)-propanone is obtained as a white solid (10.3 g). The yield is 90.0%. MS(m/z): 229.0 [M+1]+.

Workup

  1. additionis added dropwise, while the internal temperature
  2. temperatureis maintained below 5° C

Sources & evidence

ORD record
ord-c5984651998e45b4871e791a1fd1e0a1
Source dataset
uspto-grants-2015_02
Patent number
US08962621B2

Reaction notes

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