Hydrochloric Acid → HCID 59718950, compound

Participants

Reaction Steps

To a suspension of (4-benzotriazol-1-yl-pyrimidin-2-yl)-(1,4-dioxa-spiro[4.5]dec-8-yl)-amine (prepared in a similar manner as described in Example 2) (1.53 g, 4 mmol) in 80 mL of THF was added 25 mL of a 3 M aqueous solution of HCl. The reaction mixture was stirred at RT for 20 minutes. The reaction was heated to reflux for 30 minutes. It was then cooled, and poured onto an aqueous NaHCO3 solution. The resulting mixture was extracted with EtOAc, dried over Na2SO4 and filtered. The solvent was evaporated under reduced pressure until the product began to crystallize out of solution; it was then filtered and dried to give the title product as a white powder (942 mg, 70% yield); mp=204.9-206.5° C.; MS=309 (M+H)+.

Provenance & Evidence