Hydrochloric Acid → HCID 178525762, compound

Participants

Reaction Steps

An aqueous solution of NaOH (2 M, 10 mL) was added to a colorless solution of 4-(4-benzotriazol-1-yl-5-chloro-pyrimidin-2-ylamino)-cyclohexanecarboxylic acid methyl ester (482 mg, 1.25 mmol) in THF (10 mL) at RT. The reaction mixture was stirred at RT overnight; it was then diluted with water (15 mL) and acidified until pH 3 by addition of HCl (2 M). The white precipitate formed was collected by filtration, washed with water and air dried to give 435 mg (85% yield) of trans-4-(4-benzotriazol-1-yl-5-chloro-pyrimidin-2-ylamino)-cyclohexane-carboxylic acid as a white solid. MS: 373.12 (M+1)+, 345.15 ((M+1)+−28).

Provenance & Evidence