反应详情

温度

90 °C

A mixture of 18 g (50 mmol) of 1,6-dibromopyrene, 8.6 g (50 mmol) of naphthalen-1-ylboronic acid, 0.6 g (0.5 mmol) of tetrakis(triphenylphosphine) palladium, 38 ml of 2M Na2CO3, 100 ml of EtOH and 200 ml toluene was degassed and placed under nitrogen, and then heated at 90° C. for 24 h. After finishing the reaction, the mixture was allowed to cool to room temperature. The organic layer was extracted with ethyl acetate and water, dried with anhydrous magnesium sulfate, the solvent was removed and the residue was purified by column chromatography on silica (hexane-dichloromethane) to give product 8 g (40%) as a white solid.

1. customwas degassed
2. customthe reaction
3. temperatureto cool to room temperature
4. extractionThe organic layer was extracted with ethyl acetate and water
5. dry with materialdried with anhydrous magnesium sulfate
6. customthe solvent was removed
7. customthe residue was purified by column chromatography on silica (hexane-dichloromethane)