Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-Chloroethyl chloroformate | HCID 521305 | — |
| Reactant | 1-[4-(1-Benzhydryl-azetidin-3-yl)-piperazin-1-yl]-2,2,2-trifluoro-ethanone | HCID 59625975 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59625678 | HCID 59625678 | — |
Reaction Steps
To a solution of compound 1f (2.11 g, 5.23 mmol) in CH2Cl2 (60 mL) was added 1-chloroethyl chloroformate (2.0 mL, 18.35 mmol) at 0° C. under N2. The mixture was stirred at 0° C. for 90 min and then MeOH (4 mL) was added. The mixture was refluxed for 1 h. Upon cooling, Et2O (50 mL) was added to the mixture. The resulting solid was collected by filtration and dried. The crude compound 1g was used in the next reaction without further purification. MS m/z (M+H+) 238.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08962607B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-175b4ed940a0420d8b31bfa79c6c33b1 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
