HCID 69083514, compound → HCID 69082945, compound

Participants

Reaction Conditions

Reaction Steps

A solution of gold chloride triphenylphosphine (0.444 g) and silver tetrafluoroborate (0.174 g) in carbon tetrachloride was stirred for 30 min. To this solution was added a solution of 2-methyl-2-[3-(2-trifluoromethyl-phenylethynyl)-pyrazin-2-yl]-propionic acid (0.50 g). The reaction mixture was flushed out with argon then heated to 55° C. for 48 hours. The reaction mixture was cooled to ambient temperature, filtered, concentrated and the residue purified by chromatography on silica gel (eluent 5-95% ethyl acetate in isohexane) to give 8,8-dimethyl-5-[1-(2-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-5,8-dihydro-pyrano[3,4-b]pyrazin-7-one (compound D1 of Table D) (0.170 g).

Provenance & Evidence